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目的：观察丙戊酸钠与尼莫地平治疗偏头痛的疗效有否差别。方法：偏头痛１２９例，随机分为丙戊酸钠治疗组６６例（男性１７例，女性４９例；年龄２５±ｓ７ａ），丙戊酸钠开始剂量为０．２ｇ，ｐｏ，ｔｉｄ，以后根据发作频率及程度逐渐增量，最大量１．４ｇ／ｄ，共用３ｍｏ；尼莫地平对照组６３例（男性１８例，女性４５例，年龄２７±６ａ），尼莫地平３０ｍｇ，ｐｏ，ｔｉｄ，共用３ｍｏ。结果：丙戊酸钠组总有效率为８３％。尼莫地平组为８５％，２组无明显差异（Ｐ＞０．０５）．未见严重不良反应。结论：丙戊酸钠与尼莫地平治疗偏头痛安全有效、疗效相似。
Objective: To observe whether there is any difference between the efficacy of sodium valproate and nimodipine in the treatment of migraine. Methods: A total of 129 migraineurs were randomly divided into 66 cases (17 males and 49 females; age 25 ± s7a), sodium valproate (0.2 g, po, tid) The frequency and extent of seizures gradually increased, the maximum amount of 1.4g / d, sharing 3mo; nimodipine control group of 63 patients (18 males and 45 females, age 27 ± 6a), nimodipine 30mg, po, tid, Share 3mo. Results: The total effective rate of sodium valproate group was 83%. Nimodipine group was 85%, no significant difference between the two groups (P> 0.05). No serious adverse reactions. Conclusion: Sodium valproate and nimodipine are safe and effective in the treatment of migraine with similar curative effect.