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目的探讨甘露聚糖结合凝集素(MBL)在甲状腺肿瘤组织中的表达及其临床意义。方法应用免疫组化SP技术检测26例甲状腺乳头状癌(PTC)及其癌旁正常甲状腺组织和30例甲状腺腺瘤组织(TA)中MBL蛋白的表达含量;结合甲状腺乳头状癌患者的病理参数进行分析。结果 MBL在甲状腺乳头状癌、腺瘤、癌旁正常甲状腺组织中的表达分别为0.322±0.008、0.227±0.003和0.113±0.003,各组间比较,差异均有统计学意义(P<0.01);MBL表达与甲状腺癌患者的性别、年龄、分期、肿瘤大小、淋巴结有无转移无明显相关性(P>0.05)。结论 MBL可能参与了甲状腺肿瘤发生的免疫防御过程。
Objective To investigate the expression of mannan-binding lectin (MBL) in thyroid tumor and its clinical significance. Methods Immunohistochemical SP technique was used to detect the expression of MBL protein in 26 cases of thyroid papillary carcinoma (PTC), its adjacent normal thyroid tissue and 30 cases of thyroid adenoma (TA). Combined with the pathological parameters of thyroid papillary carcinoma Analyze. Results The expression of MBL in papillary thyroid carcinoma, adenoma and adjacent normal thyroid tissue were 0.322 ± 0.008, 0.227 ± 0.003 and 0.113 ± 0.003, respectively. The differences among the groups were statistically significant (P <0.01). There was no significant correlation between MBL expression and thyroid cancer patients’ sex, age, stage, tumor size and lymph node metastasis (P> 0.05). Conclusion MBL may be involved in the immune defense process of thyroid tumors.