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目的:探讨Livin及survivin表达与结肠癌发生、发展、转移及预后的关系。方法:采用免疫组化SP法检测100例结肠癌病人的癌、癌旁组织和正常结肠组织标本中Livin及survivin的表达,分析其与结肠癌发生、发展、转移及预后的关系,并通过随访研究其与5年生存率的关系。结果:Livin和Survivin在结肠癌组织中的阳性表达率均显著高于癌旁组织和正常结肠组织(P<0.05),在结肠癌组织中的表达与患者年龄、性别、肿瘤的大小和分化程度均不具有相关性(P>0.05),在有淋巴结及远处转移患者中高表达,与无转移者差异显著(P<0.05);Livin和Survivin表达阳性者5年生存率均明显低于表达阴性者(P<0.05);Livin和Survivin的表达无相关性。结论:Livin和Survivin在结肠癌的发生、发展和转移中起重要作用,对预后的判断具有一定的参考意义。
Objective: To investigate the relationship between the expression of Livin and survivin and the occurrence, development, metastasis and prognosis of colon cancer. Methods: The expression of Livin and survivin in 100 cases of colon cancer tissues, adjacent tissues and normal colon tissues was detected by immunohistochemical SP method. The relationship between Livin and survivin expression with the occurrence, development, metastasis and prognosis of colon cancer was analyzed. To study its relationship with 5-year survival rate. Results: The positive rates of Livin and Survivin in colon cancer tissues were significantly higher than those in paracancerous tissues and normal colon tissues (P <0.05). The expressions of Livin and Survivin in colon cancer tissues were significantly correlated with the age, sex, tumor size and differentiation (P> 0.05). There was a significant difference between the patients with lymph node metastasis and without metastasis (P <0.05). The 5-year survival rates of Livin and Survivin positive patients were significantly lower than those of negative patients (P <0.05). There was no correlation between the expression of Livin and Survivin. Conclusion: Livin and Survivin play an important role in the development, progression and metastasis of colon cancer, and have certain reference value for the prognosis.