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目的探讨C反应蛋白(CRP)对新生儿宫内细菌感染的诊断价值。方法选取2014年1~12月在我院产科出生,有宫内细菌感染高危因素的新生儿,根据感染结局分为感染组及无感染组,检测两组新生儿脐血、外周血CRP,比较两组新生儿脐血CRP的阳性率及CRP水平的差异性,比较感染组脐血CRP与新生儿外周血CRP水平的差异性。结果共有107例新生儿纳入研究,其中感染组30例,无感染组77例。感染组脐血CRP水平、阳性率均明显高于非感染组,感染组新生儿外周血CRP水平高于脐血CRP水平,差异均有统计学意义(P<0.05)。结论脐血CRP可作为宫内细菌感染早期诊断的参考指标,提高诊断的敏感度,指导临床抗生素使用。
Objective To investigate the diagnostic value of C-reactive protein (CRP) in neonatal intrauterine bacterial infection. Methods From January to December 2014, neonates born in obstetrics and gynecology department in our hospital with high risk of intrauterine bacterial infection were divided into infected group and non-infected group according to the infection outcome. The levels of CRP in cord blood and peripheral blood were detected in two groups The positive rate of CRP and the difference of CRP level in neonatal cord blood of two groups were compared. The difference of CRP level between cord blood and neonatal blood in infected group was compared. Results A total of 107 newborns were included in the study, of which 30 were infected and 77 were noninfected. The cord blood CRP level and the positive rate in the infection group were significantly higher than those in the non-infected group. The CRP level in neonates with infection was higher than that in cord blood (P <0.05). Conclusion Cord blood CRP can be used as a reference for early diagnosis of intrauterine bacterial infection to improve the diagnostic sensitivity and guide clinical antibiotic use.