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目的探讨分析如何提高诊断子宫腺瘤样瘤病理方法。方法本研究选取因子宫平滑肌瘤而进行子宫全部切除的389例病例,对该389例患者的临床相关资料与病理切片中符合子宫腺瘤样瘤(ATs)诊断的病例进行病理学实验分析与免疫组化观察,并结合相关文献分析子宫腺瘤样瘤(ATs)的诊断方法 ,该组患者中有18例可确诊为子宫腺瘤样瘤(ATs)。结果 18例患者的平均患病年龄46.1岁,临床表现为无症状或者月经不调、痛经。病理检查肉眼示病灶均呈实性,灰红或灰白色,界限不清。显微镜下最主要的特点是内衬扁平或立方上皮为特点,形成不规则腺腔样或裂隙样结构,且都有不同程度的平滑肌细胞的增生。18例患者的AB-PAS、HBME-1、广谱CK、MC、Vimentin、Ca lretinin、MC免疫指标阳性。CEA、CD34和F8免疫指标阴性。结论子宫腺瘤样瘤(ATs)易误诊为平滑肌瘤,且临床症状缺乏明显特异性,并常和平滑肌瘤同时发生。多处取材在病理检查过程中是避免和误诊的主要手段。
Objective To investigate how to improve the pathological diagnosis of adenomatoid tumor. Methods 389 cases of hysterectomy due to leiomyoma of the uterus were enrolled in this study. Pathological analysis was performed on the 389 cases of patients with clinically relevant data and pathological sections in line with the diagnosis of adenoma of the uterus (ATs) Immunohistochemistry and combined with related literature analysis of adenomyosis (ATs) diagnosis, 18 patients in this group of patients can be diagnosed as adenomatoid tumor (ATs). Results The average age of 18 patients was 46.1 years old. The clinical manifestations were asymptomatic or irregular menstruation and dysmenorrhea. Pathological examination shows that the naked eye showed solid lesions, gray or gray, unclear boundaries. The main feature of the microscope is lined with flat or cubic epithelium is characterized by the formation of irregular gland-like or fissure-like structure, and have varying degrees of proliferation of smooth muscle cells. 18 cases of patients with AB-PAS, HBME-1, broad-spectrum CK, MC, Vimentin, Ca lretinin, MC immune indicators were positive. CEA, CD34 and F8 immune indicators negative. Conclusions Adenoma-adenomas (ATs) are easily misdiagnosed as leiomyomas, and the clinical symptoms are not obviously specific and often occur simultaneously with leiomyomata. Multiple drawing in the pathological examination process is to avoid and misdiagnosis of the main means.