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目的观察川崎病患儿接受大剂量丙种球蛋白治疗以及护理干预前后的心功能状态,并运用Tei指数评价其治疗护理效果。方法选择90例川崎病确诊患儿,所有患儿均接受大剂量丙种球蛋白治疗,并根据是否给予精心护理干预分为无精心护理干预组(A组,45例)和精心护理干预组(B组,45例),另选择45例健康儿童作为对照组,运用Tei指数观察患儿经治疗护理前后的心功能变化。结果 3组间治疗前的左室射血分数(LVEF)、E/A值比较,差异均无统计学意义(P>0.05);A组、B组患儿治疗前的LV-Tei、RV-Tei均较对照组延长,差异有统计学意义(P<0.05);A组、B组患儿治疗后的LVEF、E/A值与治疗前比较,差异均无统计学意义(P>0.05);A组、B组患儿治疗后的LV-Tei、RV-Tei均较治疗前缩短,差异有统计学意义(P<0.05);治疗后B组患儿的LV-Tei、RV-Tei均较A组缩短,差异有统计学意义(P<0.05)。结论使用大剂量丙种球蛋白治疗川崎病患儿并给予精心护理干预,能有效改善患儿的心功能状态,而应用Tei指数能敏感地监测患儿的心功能变化。
Objective To observe the cardiac function of children with Kawasaki disease treated with high dose gamma globulin before and after nursing intervention, and to evaluate their therapeutic effect by Tei index. Methods Ninety children diagnosed with Kawasaki disease were selected and all children were treated with high dose gamma globulin. According to whether intensive care intervention was given or not, the patients were divided into two groups: control group (group A, n = 45) and intensive care group 45 cases). Another 45 healthy children were selected as the control group. The changes of cardiac function before and after treatment and nursing were observed by Tei index. Results There was no significant difference in LVEF and E / A between the three groups before treatment (P> 0.05). LV-Tei and RV- Tei were longer than the control group, the difference was statistically significant (P <0.05); LVEF, E / A value of the treatment group A, B group after treatment compared with before treatment, the difference was not statistically significant (P> 0.05) The LV-Tei and RV-Tei in both groups A and B were shorter than those before treatment (P <0.05). LV-Tei and RV-Tei Compared with group A, the difference was statistically significant (P <0.05). Conclusion The use of high-dose gamma globulin in children with Kawasaki disease and meticulous nursing intervention can effectively improve the status of children’s cardiac function, and Tei index can be sensitive to monitor changes in children’s heart function.