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据加拿大早、中孕期羊水诊断中心报道,孕早期抽羊水做产前诊断会使马蹄内翻足新生儿明显多于孕中期做产前诊断后出生的新生儿,其比例为1.3％:0.1％,P=0.000 1;胚胎丢失率也较孕中期抽羊水组有一定幅度的上升,相互比例为7.6％:5.9％。本文收集了12个加拿大产前诊断中心的早、中孕期羊水产前诊断结果,从两组间的细胞遗传学、培养成功率、母体细胞污染(MCC),核型分析中的嵌合体、诊断正确率做相互比较与分析。
According to Canada, early pregnancy, amniotic fluid diagnostic center reported that the first trimester amniotic fluid amniotic fluid prenatal diagnosis will be more than the newborn infants born after prenatal diagnosis of midwifery, the proportion of 1.3%: 0.1% , P = 0.000 1. The rate of embryo loss also increased by a certain margin compared with that of the second trimester amniotic fluid group, with the ratio of 7.6% and 5.9%. Prenatal diagnosis of prenatal amniotic fluid in early and middle trimester of 12 prenatal diagnosis centers in Canada was collected in this paper. From the aspects of cytogenetics, success rate of culture, maternal cell contamination (MCC), chimera in karyotyping, diagnosis Correct rate to compare and analyze each other.