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目的:研究急性冠脉综合征(ACS)患者血清C-反应蛋白(CRP)、脑利尿钠肽(BNP)以及D二聚体的变化情况与病情的相关性。方法:选取79例患者分为A组与B组,A组37例为急性心肌梗死患者,B组42例为不稳定型心绞痛患者,另选同期25例稳定型心绞痛患者为C组,30例健康志愿者为D组,研究四组的CRP、BNP、D二聚体水平与冠脉炎症水平的关系。结果:CRP、BNP水平以及D二聚体水平为A组>B组>C组>D组,差异有统计学意义(P<0.05),不同病变支数的CRP、BNP、D二聚体水平为三支>二支>单支,差异有统计学意义(P<0.05)。结论:CRP、BNP、D二聚体水平可有效诊断早期急性冠脉综合征,还可依照病变冠脉支数明确病情程度,具有较高的临床推广价值。
Objective: To study the relationship between the changes of serum C-reactive protein (CRP), brain natriuretic peptide (BNP) and D-dimer in patients with acute coronary syndrome (ACS). Methods: A total of 79 patients were divided into group A and group B. A group of 37 patients with acute myocardial infarction, group B 42 patients with unstable angina pectoris, another group of 25 patients with stable angina pectoris in the same period group C, 30 Healthy volunteers for the D group, study the four groups of CRP, BNP, D dimer levels and coronary artery inflammation levels. Results: The levels of CRP, BNP and D-dimer were significantly higher in group A than in group B and more in group C than in group D (P <0.05). CRP, BNP and D dimer levels in different lesion counts Three branches> two branches> one branch, the difference was statistically significant (P <0.05). Conclusion: The level of CRP, BNP and D dimer can be used to diagnose early acute coronary syndrome. It can also be used to determine the severity of coronary artery disease according to the degree of coronary artery disease, which has a high clinical value.