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目的研究甘绿解毒汤对内毒素所致中毒大鼠的解毒作用。方法将40只大鼠随机分为正常组、模型组、甘绿解毒汤组、地塞米松组4组,观察各组大鼠心肺肝肾组织病理学变化。结果甘绿解毒汤组心肾病变较模型组明显减轻甚至消失;地塞米松组肾脏病变较模型组加重,部分肾小管集合管变性坏死,心肌病变与甘绿解毒汤组无差异,肝脏病变较甘绿解毒汤组为轻;4组大鼠肺脏病变无明显差异。结论甘绿解毒汤对中毒大鼠心肝肾均有一定的保护作用,以对肾脏保护作用最明显,对肝脏的保护作用则不如地塞米松。
Objective To study the detoxification effect of Ganlv Jiedu Decoction on endotoxin-induced rats. Methods Forty rats were randomly divided into four groups: normal group, model group, Ganlu Jiedu Decoction group and dexamethasone group. Pathological changes of heart, lung, liver and kidney in each group were observed. Results Gandejiedu Decoction group of heart and kidney disease significantly reduced or even disappeared compared with the model group; dexamethasone group than the model group of renal disease lesions aggravated, part of renal tubular collection tube degeneration and necrosis, myocardial lesions and Gan Lideu Decoction group was no difference, liver disease Ganlu Jiedu Decoction group was light; there was no significant difference between the four groups in lung lesions. Conclusion Ganlu Jintu Decoction has certain protective effect on heart, liver and kidney of poisoning rats, which has the most obvious protective effect on the kidney and the protective effect on the liver is not as good as dexamethasone.