论文部分内容阅读
本文比较了一种灰黄霉素新胶囊与微粒粉剂在体内的生物利用度。制剂中不易湿润的药物,其吸收常为其溶出速率所限制。灰黄霉素是一不易溶于水的药物,在人的胃肠道中吸收缓慢和不完全。作者将药物粉碎成4μ的微粒,取25g,用2.5ml 10%丙基羟基纤维素的乙醇溶液处理,干燥后装入明胶胶囊,每粒含120mg 供体内、外试验。5名健康男子隔夜禁食后,次晨进标准餐,然后各服120mg 灰黄霉素或经处理的灰黄霉素胶囊2粒,饮水100ml,定时收集尿液并测定6-去甲灰黄霉素(6-DMG)的总量。由于口服灰黄霉素后,
This article compares the bioavailability of a new griseofulvin capsule with particulate powders in the body. Drugs that are not readily wettable in the formulation are often absorbed to their dissolution rate. Griseofulvin is a poorly water-soluble drug that absorbs slowly and incompletely in the human gastrointestinal tract. The drug was pulverized into 4μ microparticles, take 25g, with 2.5ml of 10% propylhydroxycellulose ethanol solution, dried and filled into gelatin capsules, each containing 120mg donor in vitro and in vivo tests. Five healthy men overnight fasting, the next morning into the standard meal, and each serving 120mg griseofulvin or treated griseofulvin capsules 2, drinking water 100ml, regular urine collection and determination of 6- The total amount of mycin (6-DMG). Due to oral griseofulvin,