The uplift and exhumation process in the Tianshan orogen since the late Paleozoic were likely related to the preservation of ore deposits. This study involved reconstructing the whole tectonic thermal history of the Ouxidaban pluton in central South Tianshan Mountains based on hornblende/plagioclase Ar-Ar and zircon/apatite(U-Th)/He methods. The thermal history and uplift process of central South Tianshan Mountains since the late Paleozoic were analyzed according to the results of previous works and cooling/exhumation rate features. The hornblende yields a plateau age of 382.6±3.6 Ma, and the plagioclase yields a weighted mean age of 265.8±4.9 Ma. The Ouxidaban pluton yields weighted mean zircon(U-Th)/He age of 185.8±4.3 Ma and apatite(U-Th)/He age of 31.1±2.9 Ma, respectively. Five stages of tectonic thermal history of South Tianshan Mountains since the late Paleozoic could be discriminated by the cooling curve and modeling simulation:(1) from the latest Silurian to Late Devonian, the average cooling rate of the Ouxidaban pluton was 7.84°C/Ma;(2) from the Late Devonian to the latest Middle Permian, the average cooling rate was about 2.07°C/Ma;(3) from the latest Middle Permian to the middle Eocene, the cooling rate decreased to about 0.68°C/Ma, suggesting that the tectonic activity was gentle at this time;(4) a sudden increase of the cooling rate(5.00°C/Ma) and the exhumation rate(0.17 mm/a), and crustal exhumation of ~1.83 km indicated that the Ouxidaban pluton would suffer a rapid uplift event during the Eocene(~46?35 Ma);(5) since the middle Eocene, the rapid uplift was sustained, and the average cooling rate since then has been 1.14°C/Ma with an exhumation rate of about 0.04 mm/a and an exhumation thickness of 1.33 km. The strong uplift since the Cenozoic would be related to a far-field effect from the Indian and Eurasian plates’ collision. However, it was hysteretic that the remote effect was observed in the Tianshan orogenic belt. The uplift and exhumation process in the Tianshan orogen since the late Paleozoic were likely related to the preservation of ore deposits. This study involved reconstructing the whole tectonic thermal history of the Ouxidaban pluton in central South Tianshan Mountains based on hornblende / plagioclase Ar-Ar and The thermal history and uplift process of central South Tianshan Mountains since the late Paleozoic were analyzed according the the previous works and cooling / exhumation rate features. The hornblende yields a plateau age of 382.6 ± 3.6 Ma, and the plagioclase yields a weighted mean age of 265.8 ± 4.9 Ma. The Ouxidaban pluton yields weighted mean zircon (U-Th) / He age of 185.8 ± 4.3 Ma and apatite (U-Th) / He age of 31.1 ± 2.9 Ma, respectively. Five stages of tectonic thermal history of South Tianshan Mountains since the late Paleozoic could be discriminated by the cooling curve and modeling simulation: (1) from the latest Silurian to Late Devonian, the average cooling rate of the Ouxidaban pluton was 7.84 ° C / Ma; (2) from the Late Devonian to the latest Middle Permian, the average cooling rate was about 2.07 ° C / Ma; (3) from the latest Middle Permian to the suggesting that the tectonic activity was gentle at this time; (4) a sudden increase of the cooling rate (5.00 ° C / Ma) and the exhumation rate (0.17 mm / a), and crustal exhumation of ~ 1.83 km indicated that the Ouxidaban pluton would suffer a rapid uplift event during the Eocene (~ 46? 35 Ma); (5) since the middle Eocene, the rapid uplift was sustained, and the average cooling rate since then has been 1.14 ° C / Ma with an exhumation rate of about 0.04 mm / a and an exhumation thickness of 1.33 km. The strong uplift since the Cenozoic would be related to a far-field effect from the Indian and Eurasian plates ’collision. However, it was hysteretic that the remote effect was observed in the Tianshan orogenic belt.