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目的观察微量元素变化与铁、碘缺乏大鼠甲状腺功能变化之间的关系。方法健康SPF/VAF级初断乳SD大鼠32只,雌雄各半,按体重随机分为碘铁联合缺乏组(IFD)、碘缺乏组(ID)、铁缺乏组(FD)和对照组(N),每组各8只。通过饲料控制4周使各组大鼠铁、碘营养水平达到实验预期。测定尿碘浓度、甲状腺重量、血红蛋白、血清甲状腺激素和促甲状腺激素水平,测量血清中镁(Mg)、钙(Ca)、铬(Cr)、锰(Mn)、铜(Cu)、锌(Zn)和硒(Se)的含量。结果大鼠碘营养和铁营养各项指标均符合试验设计要求。与对照组相比,铁缺乏组、碘缺乏组、碘铁联合缺乏组均出现甲状腺功能减退(甲减)或甲减趋势;碘铁联合缺乏组大鼠血清Ca、Mn、Zn浓度增加(P<0.05,P<0.01),其他元素变化无统计学意义;碘缺乏组大鼠血清Cu、Zn、Se浓度增加(均P<0.05),其他元素变化无统计学意义;铁缺乏组大鼠血清Ca、Zn浓度增加(P<0.05,P<0.01),其他元素变化无统计学意义。结论多种微量元素的变化可能协同铁、碘对甲状腺的功能产生影响。
Objective To observe the relationship between the changes of trace elements and the changes of thyroid function in rats with iron deficiency and iodine deficiency. Methods Thirty-two SPF / VAF primary weaning SD rats were randomly divided into Iodine Fever Deficiency Group (IFD), Iodine Deficiency Group (ID), Iron Deficiency Group (FD) and control group N), each group of eight. After 4 weeks of feed control, the iron and iodine nutrition of rats in each group reached the experimental expectation. Urinary iodine concentration, thyroid weight, hemoglobin, serum thyroid hormone and thyroid stimulating hormone levels were measured. Serum Mg, Ca, Cr, Mn, Cu, Zn ) And selenium (Se) content. Results The indicators of iodine nutrition and iron nutrition in rats all met the experimental design requirements. Compared with the control group, the hypothyroidism (hypothyroidism) or hypothyroidism tended to occur in the iron deficient group, the iodine deficiency group, and the iodine-iron combined deficient group. The serum Ca, Mn and Zn concentrations in the iodine-iron combined deficient group increased (P (P <0.05, P <0.01, P <0.01). The concentrations of Cu, Zn and Se in iodine deficiency group increased (all P <0.05), but the other elements had no statistical significance. Ca, Zn concentration increased (P <0.05, P <0.01), other elements had no significant change. Conclusion The changes of many trace elements may have synergistic effects with iron and iodine on thyroid function.