近年来,许多药物效应受遗传因素控制变得更加明显了,下面以一些例证介绍药理遗传学的有关现状。Ⅰ:基因与药物代谢 1.琥珀酰胆硷的水解遗传控制药物代谢的明显例子是人体血浆中的胆硷酯酶变异型。血浆胆硷酯酶能水解多种药物,但有临床意义的是对肌松剂琥珀酰胆硷的作用,在异常胆硷酯酶存在下, In recent years, many drug effects by genetic factors become more apparent, the following to introduce some of the current status of pharmacological genetics. Ⅰ: Gene and Drug Metabolism 1. Hydrolytic Genetic Control of Succinylcholine A clear example of drug metabolism is the cholinesterase variant in human plasma. Plasma cholinesterase can hydrolyze a variety of drugs, but the clinical significance of the role of muscle relaxant succinylcholine in the presence of abnormal cholinesterase,