论文部分内容阅读
目的探讨环氧化酶-2(COX-2)、Fax、Ki-67在宫颈癌中的表达及其临床病理意义。方法采用免疫组织化学染色的方法 ,检测宫颈癌(cervical cancer,CC)40例,宫颈上皮内瘤变(cervical intraepithelial neoplasm,CIN)10例及正常宫颈组织(normal cervical epithelium,NCE)9例中COX-2、Fax、Ki-67的抗体表达的情况。结果 COX-2在宫颈癌中的表达率为70%~90%,而在正常宫颈组织及宫颈上皮内瘤变中表达率比较差异无统计学意义(P>0.05)。Fax在宫颈癌中的阳性表达率明显低于正常宫颈组织和CIN组织(P<0.05);Ki-67在宫颈癌、CIN与正常宫颈组织中表达差异有统计学意义(P<0.05)。结论 COX-2、Fax、Ki-67在宫颈癌的发生、发展及淋巴结转移中有着重要作用,可以作为判断宫颈癌恶性程度及淋巴结转移的生物学指标。
Objective To investigate the expression of Cyclooxygenase-2 (COX-2), Fax, Ki-67 in cervical cancer and its clinicopathological significance. Methods Immunohistochemical staining was used to detect the expression of COX in 40 cases of cervical cancer (CC), 10 cases of cervical intraepithelial neoplasm (CIN) and 9 cases of normal cervical epithelium (NCE) -2, Fax, Ki-67 antibody expression. Results The expression of COX-2 in cervical cancer was 70% -90%, while there was no significant difference between normal cervical tissue and cervical intraepithelial neoplasia (P> 0.05). The positive expression rate of Fax in cervical cancer was significantly lower than that in normal cervical tissues and CIN tissues (P <0.05). The expression of Ki-67 in cervical cancer, CIN and normal cervical tissues had statistical significance (P <0.05). Conclusions COX-2, Fax and Ki-67 play an important role in the carcinogenesis and progression of cervical cancer and lymph node metastasis. They can be used as biological indicators to evaluate the malignancy and lymph node metastasis of cervical cancer.