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本文介绍40例反复发作的支气管哮喘,用药物治疗同时配合支气管肺泡灌洗(BAL)术治疗,并同期设单纯药物对照组。经BAL 术1～6次治疗缓解38例,总有效率达95%,对照组为80%(P<0. 05) .经纤支镜肉眼与病理检查均见气管粘腱充血、水肿,但大部分光滑,有粘稠分泌物附着,22例于第3级支气管开口处见支气管痉挛现象,经治疗1～3次后支气管痉挛现象消失.病理检查提示支气管粘膜粗糙、增生及慢性炎症.治疗后复查肺功能见FEF25～75%改善(p<0. 05) .血气分析PaO_2上升,而对照组变化不大.有28例在肺泡灌洗液中查到肺炎双球菌、甲型链球菌,绿脓杆菌等.IgM、IgE 含量增高.从而进一步证明哮喘的发作常有感染与过敏因素同时存在.
This article describes 40 cases of recurrent bronchial asthma, with drug treatment at the same time with bronchial alveolar lavage (BAL) treatment, and the same period a simple drug control group. After 1 ~ 6 times of BAL surgery, 38 cases were relieved, the total effective rate was 95% and that of the control group was 80% (P <0.05) .There was congestion and edema of the tracheal adhesions in the trachea Most of the smooth, viscous secretions attached, 22 cases of bronchial spasm seen in the third grade bronchial spasm, after treatment of 1 to 3 times bronchospasm disappeared .Pathological examination prompted bronchial mucosa rough, hyperplasia and chronic inflammation. After review of pulmonary function, see FEF25 ~ 75% improvement (p <0.05) .PaO_2 blood gas analysis increased, while the control group changed little.Of the 28 cases found in the bronchoalveolar lavage pneumococcal, streptococcus, Pseudomonas aeruginosa, etc .. IgM, IgE levels increased, thus further evidence of asthma attacks and allergic factors often exist.