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胃复安作为止吐剂,笔者曾遇6例在常用剂量给药后发生锥体外系症状.为了提高对胃复安神经系统副作用的识别和重视,现报告如下.一病历摘要(附表)二、讨论1.此组病例在服用胃复安后出现椎体外系症状(如附表).本组病人既往无类似发作史,停药后应用安定及抗胆硷药物治疗有效.2.胃复安引起锥体外系症状的发病机制,是由于胃复安为纹状体内的多巴胺拮抗剂。在纹状体
Metoclopramide as an antiemetic agent, I have encountered in 6 cases after the usual dose of extrapyramidal symptoms occurred in order to improve the side effects of metoclopramide identification and attention, are as follows. A medical summary (Schedule) Second, the discussion 1. This group of patients in the presence of metoclopramide after extra-vertebral system symptoms (such as schedule.) This group of patients in the past without a similar history of seizures, withdrawal after the application of diazepam and anticholinergic drugs effective. Metoclopramide induced extrapyramidal symptoms of the pathogenesis is due to metoclopramide in the striatum of dopamine antagonists. In the striatum