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目的 血清ｓＩＣＡＭ１、ｓＣＤ８ 在胆囊癌中变化及意义。方法 ＥＬＩＳＡ法。结果 胆囊癌患者血清ｓＩＣＡＭ１ 水平（２．６２±１．９７μｇ／ｍ ｌ）高于正常组（０．５２±０．１５μｇ／ｍ ｌ），中晚期组（２．９７±２．０８μｇ／ｍ ｌ）高于早期组（１．３８±０．６７μｇ／ｍｌ），且早期组（１．３８±０．６７μｇ／ｍｌ）高于正常组（０．５２±０．１５μｇ／ｍ ｌ），Ｐ均＜ ０．０１，有显著性差异。血清ｓＣＤ８ 水平（１８．６７±１１．７ｕ／ｌ）高于正常组（９．８９±３．１３ｕ／ｌ），中晚期组（２１．３８±１１．８ｕ／ｌ）高于早期组（８．９３±３．１３ｕ／ｌ），Ｐ均＜ ０．０１，差异显著。血清ｓＩＣＡＭ１ 水平与ｓＣＤ８ 呈正相关。结论 血清ｓＩＣＡＭ１、ｓＣＤ８ 水平与胆囊癌病情、预后密切相关。
Objective To investigate the changes and significance of serum sICAM-1 and sCD8 in gallbladder carcinoma. Methods ELISA. Results Serum sICAM-1 level in patients with gallbladder carcinoma was higher (2.62±1.97 μg/ml) than that of normal group (0.52±0.15 μg/ml), and that of middle-late group (2.97±2.08 μg/ml). m l) was higher than that of the early group (1.38±0.67 μg/ml), and the early group (1.38±0.67 μg/ml) was higher than the normal group (0.52±0.15 μg/ml). P < 0.01, there is a significant difference. The serum sCD8 level (18.67±11.7u/l) was higher than the normal group (9.89±3.13u/l), and the middle-late group (21.38±11.8u/l) was higher than the early group (8 .93±3.13u/l), P<0.01, significant difference. Serum sICAM-1 levels were positively correlated with sCD8. Conclusion Serum levels of sICAM-1 and sCD8 are closely related to the condition and prognosis of gallbladder carcinoma.