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洋地黄的治疗剂量范围狭窄,具有中毒的危险性。据新近文献报告,洋地黄中毒发生率为5～35％,故使用洋地黄时必须审慎。有谓在肾功能正常和无电解质紊乱的情况下,用标准洋地黄化法可以减少洋地黄中毒的发生,还可确保达到满意的洋地黄化。为此,作者对310例患者以地高辛和β-乙酰地高辛,分别按标准洋地黄化法和非标准洋地黄化法进行治疗,并测定出其血浆强心甙浓度,对这两种给药方法进行对比研究。
Digitalis treatment of a narrow dose range, with the risk of poisoning. According to recent reports, the incidence of digitalis poisoning is 5 to 35%, so the use of digitalis must be careful. It is said that with normal renal function and electrolyte-free disorders, standard digitalis can reduce the incidence of digitalis intoxication and ensure satisfactory digitalisation. To this end, the authors of 310 patients with digoxin and β-acetyl digoxin, respectively, according to the standard method of digitalis and non-standard method of digitalis treatment and determination of plasma concentrations of cardiac glycosides, the two Methods of administration were compared.