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目的探讨酒精性肝病(Alcoholic liver disease,ALD)发病情况、临床特征。方法回顾性分析85例酒精性肝病患者,包括饮酒年限、饮酒量、生活方式是否合并其他疾病如乙肝、丙肝、2型糖尿病、血脂异常等,并进行综合分析。结果饮酒量大于150 g/d,且持续5年以上者,患酒精性肝病的几率明显增加,在合并有病毒性肝炎、糖尿病、血脂异常的情况下,发展为肝硬化的可能性更大。结果ALD患者的致病因子明确,日均酒精摄入量和饮酒年限与酒精性肝病的肝脏损伤程度呈明显正相关,治疗后饮酒者预后差,死亡的主要原因是肝硬化的晚期并发症。结论相同饮酒量及饮酒年限的患者因其疾病进程、环境和遗传因素的不同,导致个体间对酒精毒性的反应也不同。ALD病情和预后与长期大量饮酒有关。有饮酒嗜好的患者应劝其戒酒,并定期监测肝功能指标,及早进行治疗,以改善预后。
Objective To investigate the incidence and clinical characteristics of alcoholic liver disease (ALD). Methods A retrospective analysis of 85 cases of alcoholic liver disease patients, including drinking time, alcohol consumption, lifestyle and other diseases such as hepatitis B, hepatitis C, type 2 diabetes, dyslipidemia, and a comprehensive analysis. Results Alcohol consumption greater than 150 g / d for more than 5 years increased the risk of alcoholic liver disease, and was more likely to develop cirrhosis with viral hepatitis, diabetes and dyslipidemia. Results The pathogenic factors of patients with ALD were clear, and the average daily alcohol intake and drinking duration were positively correlated with the degree of liver damage in alcoholic liver disease. The prognosis of alcoholic patients was poor after treatment. The main cause of death was late complications of liver cirrhosis. Conclusions Patients with the same alcohol intake and alcohol consumption experience different responses to alcohol toxicity due to differences in disease progression, environmental and genetic factors. ALD disease and prognosis and long-term heavy drinking related. Patients with alcoholism should be advised to abstain from alcohol, and regular monitoring of liver function indicators, early treatment, to improve the prognosis.