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目的观察分析妊娠期高血疾病孕妇血清中α1-微球蛋白(α1-MG)、C-反应蛋白(CRP)、血浆D-二聚体(D-D)的变化规律及其临床意义。方法回顾性分析2015年10月-2016年12月该院妊娠期高血压疾病孕妇52例为研究组,同期健康孕妇及未孕妇女82例为对照组。采用全自动生化分析仪测定各组孕妇血清中α1-MG、CRP含量,采用全自动血凝仪测定各组孕妇血浆D-D含量。结果研究组孕妇血清中的α1-MG、CRP、D-D浓度均高于对照组,且子痫孕妇要高于子痫前期孕妇,重度子痫前期孕妇高于轻度子痫前期孕妇。结论妊娠期高血压疾病孕妇血清α1-MG、CRP、血浆D-D含量随病情加重而增高。动态监测孕妇血清中α1-MG、CRP、血浆D-D浓度可作为妊娠期高血压疾病诊断、病情监控及防治并发症保护母婴安全的良好指标。
Objective To observe the changes and clinical significance of serum α1-microglobulin (α1-MG), C-reactive protein (CRP) and plasma D-dimer in pregnant women with gestational hypertension. Methods A retrospective analysis of 52 cases of pregnant women with hypertensive disorder complicating pregnancy in our hospital from October 2015 to December 2016 was taken as the study group. 82 healthy pregnant women and nonpregnant women in the same period were taken as the control group. The contents of α1-MG and CRP in serum of pregnant women in each group were determined by automatic biochemical analyzer. The content of D-D in plasma of pregnant women was measured by automatic coagulation analyzer. Results The concentrations of α1-MG, CRP and D-D in serum of pregnant women in study group were higher than those in control group. The levels of serum and serum of pregnant women with eclampsia were higher than those of pregnant women with preeclampsia and those with severe preeclampsia than those with mild preeclampsia. Conclusion The serum levels of α1-MG, CRP and plasma D-D in pregnant women with hypertensive disorder complicating pregnancy increase with the severity of the disease. Dynamic monitoring of maternal serum α1-MG, CRP, plasma D-D concentrations can be used as a good indicator of maternal and child health in the diagnosis of pregnancy-induced hypertension, disease monitoring and prevention of complications.