论文部分内容阅读
【目的】通过对新生儿高促甲状腺素血症患儿转归的研究,为先天性甲状腺功能减低症的治疗工作提供依据。【方法】对446例经新生儿疾病筛查可疑先天性甲状腺功能减低症、第1次就诊时静脉血清促甲状腺激素(thy-rotropin,TSH)浓度为5～20mU/L、FT4浓度正常的新生儿随访至3～6岁后,评估体格发育情况与甲状腺功能。【结果】1)经3～6年随访,最后确诊永久性甲状腺功能低下1例,高TSH血症16例,甲状腺功能完全正常429例;2)随访起始与结束时TSH浓度比较,Z值分别为:2.90,5.41,6.45,P值均为<0.01。【结论】经新生儿疾病筛查的高TSH血症患儿多数可恢复正常,少数应严密随访,以早期确诊及治疗。
【Objective】 Through the research on the outcome of neonates with hyperkaline thyroiditis, it provides the basis for the treatment of congenital hypothyroidism. 【Methods】 446 cases of suspected neonatal hypothyroidism were screened for suspicious congenital hypothyroidism. At the first visit, the concentration of thyroid-stimulating hormone (TSH) was 5 ~ 20mU / L, and the level of FT4 was normal Children were followed up to 3 to 6 years old to assess physical development and thyroid function. 【Results】 1) After 3 to 6 years of follow-up, the final diagnosis of permanent hypothyroidism in 1 case, 16 cases of hyper-TSH hyperlipidemia, thyroid function completely normal in 429 cases; 2) Follow-up at the beginning and end of TSH concentration, Z value Respectively: 2.90,5.41,6.45, P <0.01. 【Conclusion】 The majority of children with high TSH hyperlipidemia who have been screened for neonatal disease can return to normal, and a minority of them should be closely followed up for early diagnosis and treatment.