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目的对绝经后萎缩性阴道炎患者给予雌三醇软膏和乳酸菌胶囊阴道用药,评价其疗效并观察患者阴道乳杆菌及pH变化。方法将2013年9月~2015年9月笔者所在医院妇科门诊接治的160例萎缩性阴道炎女性患者按照随机数字表法均分2组,均给予我科针对萎缩性阴道炎患者的常规治疗,在此基础上再对试验组80例患者给予阴道内局部应用雌三醇软膏和乳酸菌胶囊,治疗结束后在随访期内对两组患者治疗效果及阴道乳杆菌、pH变化进行综合比较。结果试验组患者阴道乳杆菌阳性检出率达到73.75%,而对照组仅51.25%,组间比较有显著性差异(P<0.05),同时试验组菌落大于1/2面积的患者比例明显高于对照组(P<0.05);试验组阴道p H检测结果为(4.60±0.65),对照组为(5.92±0.88),提示试验组患者阴道酸碱度环境更佳(P<0.01);随访期间,试验组患者痊愈及好转例数达到73例,治疗有效率为91.25%;对照组患者痊愈及好转例数有61例,治疗有效率为76.25%;组间治疗总有效率比较有显著性差异(P<0.05)。结论对照研究表明给予绝经后萎缩性阴道炎患者雌三醇软膏和乳杆菌胶囊阴道用药能够有效促进阴道菌群恢复,维持阴道内正常酸性环境,巩固药物治疗效果。
Objective To evaluate the efficacy of vaginal administration of estriol ointment and lactic acid bacteria capsules in patients with post-menopausal atrophic vaginitis and to observe the change of vaginal lactobacilli and pH in patients. Methods A total of 160 women with atrophic vaginitis who were treated at the gynecology clinic of our hospital from September 2013 to September 2015 were divided into two groups randomly according to the random number table. All of them were given routine treatment of atrophic vaginitis On the basis of this, 80 patients in the experimental group were given intravaginal topical application of estriol ointment and lactic acid bacteria capsules. After treatment, the treatment effect and changes of pH of vaginal lactobacilli and bacteria in two groups were compared during the follow-up period. Results The positive rate of Lactobacillus in test group was 73.75%, while it was only 51.25% in control group (P <0.05). Meanwhile, the proportion of colonies with more than 1/2 area in test group was significantly higher than that in test group (4.60 ± 0.65) in the test group and (5.92 ± 0.88) in the control group, suggesting that the vaginal pH value of the test group was better (P <0.01). During the follow-up period, In the group of patients, 73 cases were cured and improved, the effective rate was 91.25%. In the control group, 61 cases were cured and improved, and the effective rate was 76.25%. The total effective rate was significantly different between groups (P <0.05). Conclusions The control study shows that administration of estriol ointment and Lactobacillus capsules to postmenopausal women with atrophic vaginitis can effectively promote the recovery of vaginal flora, maintain normal intravaginal acidic environment and consolidate the therapeutic effect of drugs.