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目的评价为急性缺血性脑卒中患者在发病3h内进行静脉溶栓的疗效。方法在为我院收治的72例急性缺血性脑卒中患者进行治疗的过程中,将他们平均分为溶栓组和对照组,为溶栓组患者使用RT-PA进行治疗,为对照组患者使用低分子肝素进行治疗。根据爱丁堡斯堪的那维亚改良评分法(CSS),记录患者在治疗前及治疗后6h、24h、3d、14d及21d的神经功能缺损评分,记录其治疗后14d及28d日常生活能力量表(ADL),评定两组患者的疗效。结果溶栓组患者神经功能的改善情况明显优于对照组患者(P<0.01),其日常生活能力也优于对照组患者(P<0.01)。结论早期(3h以内)使用RT-PA治疗急性缺血性脑卒中疗效确切,安全性较高,值得在临床上推广使用。
Objective To evaluate the efficacy of intravenous thrombolysis in patients with acute ischemic stroke within 3 hours of onset. Methods During the treatment of 72 patients with acute ischemic stroke admitted to our hospital, they were equally divided into thrombolytic group and control group. Patients in thrombolytic group were treated with RT-PA, which was the control group Use low molecular weight heparin for treatment. According to Scandinavia Edinburgh Scoring System (CSS), the neurological deficit scores of patients before and 6h, 24h, 3d, 14d and 21d after treatment were recorded, and the daily living ability scale of 14d and 28d after treatment were recorded (ADL), assess the efficacy of two groups of patients. Results The improvement of neurological function in thrombolytic group was significantly better than that in control group (P <0.01), and its daily living ability was superior to that in control group (P <0.01). Conclusion The early (within 3h) use of RT-PA in the treatment of acute ischemic stroke has definite curative effect and high safety. It is worth to be popularized in clinic.