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目的探究硫酸镁注射剂不良反应发生的一般规律及预防。方法选取苍南县妇幼保健院2013年2月—2014年4月药品监测中心统计的因硫酸镁注射剂引起不良反应的116例患者,分析其原因。结果用药患者中20~39岁女性所占比例为72.4%;患者的不良反应主要发生在30min内,发生率为68.9%;不良反应主要累及胃肠系统,所占比例为74.9%,全身损伤所占比例为25.1%,停药后给予积极有效治疗,痊愈率为45.7%,好转率为54.3%。结论硫酸镁注射剂不良反应女性的发生率较高,且主要集中在用药30min内,多累及胃肠系统。为减少硫酸镁注射剂不良反应的发生,临床应加强硫酸镁的用药监测,并不断完善使用说明书。
Objective To investigate the general rules and prevention of adverse reactions of magnesium sulfate injection. Methods A total of 116 patients with side effects caused by magnesium sulfate injection in Cangnan Maternal and Child Health Hospital from February 2013 to April 2014 were selected and their causes were analyzed. Results The proportion of women aged 20-39 years old was 72.4%. The adverse reactions occurred mainly in 30 minutes (68.9%). The adverse reactions mainly involved the gastrointestinal system, accounting for 74.9% of the total. Accounting for 25.1%. After stopping treatment, they were given active and effective treatment. The cure rate was 45.7% and the improvement rate was 54.3%. Conclusion The incidence of adverse reactions of magnesium sulfate injection in women is high, and mainly concentrated in the medication within 30min, involving the gastrointestinal system. In order to reduce the occurrence of adverse reactions of magnesium sulfate injection, clinical monitoring of the use of magnesium sulfate should be strengthened and the instructions for use should be continuously improved.