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目的探讨眼睑基底细胞癌中Survivin与NF-κBP65的表达及相关性。方法采用免疫组织化学SP法检测35例眼睑基底细胞癌及20例正常眼睑组织中Survivin与NF-κBP65的表达情况。结果 Survivin在正常眼睑组织细胞中呈阴性表达,在眼睑基底细胞癌中呈阳性表达,达85.7%,在眼睑正常组织细胞中与肿瘤组织细胞中的表达有统计学差异(P<0.05)。NF-κBP65在正常眼睑组织细胞中表达率15%,在眼睑基底细胞癌中表达率68.5%,有统计学差异(P<0.05)。Survivin与NF-κB的表达密切相关。结论 Survivin与NF-κBP65在基底细胞癌的发生中起重要作用,两者密切相关。
Objective To investigate the expression and correlation of Survivin and NF-κB P65 in eyelid basal cell carcinoma. Methods The expressions of Survivin and NF-κB P65 in 35 cases of basal cell carcinoma of the eyelid and 20 cases of normal eyelid tissues were detected by immunohistochemical SP method. Results Survivin was negatively expressed in normal eyelid cells and positive in eyelid basal cell carcinoma, accounting for 85.7%. There was a significant difference (P <0.05) in the expression of Survivin in eyelid normal cells and tumor cells. The expression rate of NF-κBP65 was 15% in normal eyelid cells and 68.5% in eyelid basal cell carcinoma (P <0.05). Survivin is closely related to the expression of NF-κB. Conclusions Survivin and NF-κB P65 play an important role in the occurrence of basal cell carcinoma, which are closely related to each other.