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为进一步探讨ADPR的生物学功能,本文设计并合成了用天门冬氨酸二肽代替焦磷酸结构的一类新型ADPR类似物。通过以5’-氨基腺苷或其模拟物为起始原料,采用类似于液相肽的合成方法,成功地构建了四个目标分子,其结构经1HNMR、HRMS等进行了鉴定。本研究为新型ADPR类似物的合成提供了一条便利途径。
In order to further explore the biological function of ADPR, a novel class of ADPR analogs with aspartic acid dipeptide instead of pyrophosphate structure was designed and synthesized. Four target molecules were successfully constructed by using 5’-amino-adenosine or its analogue as raw materials and similar to liquid phase peptide synthesis. Its structure was identified by 1HNMR, HRMS and so on. This study provides a convenient way for the synthesis of novel ADPR analogues.