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通过遗传流行病学病例对照方法，对宜兴市２１４个家系（１０９个脑梗塞先证家系和１０５个对照家系）进行分离比、多基因遗传方式和遗传度的分析。结果表明：在病例和对照家系具有良好均衡可比性的前提下，脑梗塞的分离比为０．０５２９，显著低于０．２５，说明其不符合单基因遗传病的特征；多基因遗传方式的分析表明，其一级亲属的理论发病率为６．６７８％，与实际发病率８．６１１％相比，无统计学显著性差异，符合多基因遗传的特征；遗传度的估算显示；脑梗塞先证者的一级亲属中，遗传度为５３％，其中女性亲属的遗传度达５７％，显著高于男性亲属的３９．４％，说明在脑梗塞病因中，遗传因素起着一定的作用，特别是对女性作用更明显
Through the genetic epidemiological case-control method, 214 families (109 cerebral infarction progeny and 105 control pedigrees) in Yixing City were analyzed for their segregation ratio, polygenic inheritance and heritability. The results showed that the ratio of cerebral infarction was 0.0529, which was significantly lower than 0.25 on the premise of a well balanced and comparable family and control families, indicating that it is not consistent with the characteristics of single-gene genetic disease; polygenetic inheritance Analysis shows that the first-degree relatives of the theoretical incidence rate of 6.678%, compared with the actual incidence of 8.611% compared to no statistically significant difference, in line with the characteristics of polygenic inheritance; estimates of genetic degrees; cerebral infarction First-degree relatives of probands, the heritability was 53%, of which the relatives of female relatives reached 57%, significantly higher than the male relatives 39.4%, indicating that the cause of cerebral infarction, genetic factors play a role , Especially for women more obvious role