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目的观察原发性高血压患儿血浆中硫化氢(H2S)与同型半胱氨酸(Hcy)代谢间的关系,探讨其在高血压发病中的病理生理学意义。方法北京大学第一医院儿科等单位于2005-02随机选取体检时高血压儿童(高血压组)25例,血压正常儿童30例(对照组),对其血压进行测量及体格检查,对家族史进行调查。利用荧光偏振免疫法检测血浆Hcy浓度,应用敏感硫电极法测定血浆H2S浓度。结果高血压组儿童血浆Hcy为(12·68±9·69)μmol/L,对照组儿童血浆Hcy为(6·62±4·79)μmol/L,差别有显著性意义(P<0·01);高血压组血浆H2S为(51·93±6·01)μmol/L,对照组儿童血浆H2S为(65·70±5·50)μmol/L,差别有显著性意义(P<0·01)。将血浆Hcy与H2S浓度做直线相关分析,结果呈负相关(r=-0·379,P<0·05)。将收缩压与H2S/Hcy比值作直线相关分析,结果二者呈明显负相关(r=-0·687,P<0·05)。结论原发性高血压儿童存在硫化氢与H2S代谢失衡。
Objective To observe the relationship between plasma hydrogen sulfide (H2S) and homocysteine (Hcy) metabolism in children with essential hypertension, and to explore its pathophysiological significance in the pathogenesis of hypertension. Methods Pediatrics and other units of Peking University First Hospital in 2005-02 randomly selected 25 cases of hypertensive children (hypertension group) and 30 cases of normotensive children (control group) at the time of physical examination, blood pressure was measured and physical examination, family history Investigate. Plasma Hcy concentration was measured by fluorescence polarization immunoassay, and plasma H2S concentration was measured by sensitive sulfur electrode method. Results The Hcy in plasma of hypertensive children was (12.68 ± 9.69) μmol / L and that of control children was (6.22 ± 4.79) μmol / L, with significant difference (P <0. The plasma H2S level was (51 · 93 ± 6 · 01) μmol / L in the hypertension group and (65 · 70 ± 5 · 50) μmol / L in the control group (P <0 01) · 01). The plasma Hcy and H2S concentration linear correlation analysis, the results were negatively correlated (r = -0.379, P <0.05). The systolic blood pressure and H2S / Hcy ratio for linear correlation analysis showed a significant negative correlation between the two (r = -0.687, P <0.05). Conclusion There is imbalance between the metabolism of hydrogen sulfide and H2S in children with essential hypertension.