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脑利钠肽(BNP)是一种主要由心室肌细胞合成和分泌的多肽类心脏激素,它和相应的N端残基即N末端脑钠肽原(NT-proBNP)一起,当心室壁张力升高时分泌量增加。冠心病心肌缺血可导致心脏收缩和舒张功能障碍,使心室壁张力增加,BNP和NT-proBNP释放增多。目前已有越来越多的研究表明BNP和NT-proBNP同缺血性心脏病密切相关,其水平可以反映心肌缺血程度、评价左心室收缩与舒张功能不全、预后评估及治疗指导,具有一定的临床应用前景。作者通过查阅近年来国内外相关文献并加以分析、整理和总结,就BNP和NT-proBNP的基本理论及其在冠心病领域的临床应用作一综述。
Brain natriuretic peptide (BNP) is a peptide-derived cardiac hormone that is synthesized and secreted mainly by ventricular myocytes and, along with the corresponding N-terminal residue, NT-proBNP, Increased secretion increased. Coronary heart disease myocardial ischemia can lead to systolic and diastolic dysfunction, increased ventricular wall tension, BNP and NT-proBNP release increased. More and more studies have shown that BNP and NT-proBNP are closely related to ischemic heart disease, the level can reflect the degree of myocardial ischemia, left ventricular systolic and diastolic dysfunction evaluation, prognosis evaluation and treatment guidance, with a certain Clinical application prospects. The author reviews the related literature at home and abroad in recent years and analyzes, collate and summarize the basic theory of BNP and NT-proBNP and its clinical application in the field of coronary heart disease.