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根据放射受体分析法的基本原理,应用人甲状腺激素受体,125IhTSH作为示踪物建立了促甲状腺激素受体抗体(TRAb)放射受体分析法。结果:测定未经治疗的甲状腺机能亢进症(甲亢)9例,TRAb全部呈阳性;药物治疗中的甲亢38例,其中30例阳性;正常对照组及单纯性甲状腺肿大患者组均为阴性。结果提示:本法测定TRAb可作为甲亢诊断和预后判断的方法之一。
According to the basic principle of radioimmunoassay, thyrotropin receptor antibody (TRAb) radioactive receptor assay was established by using human thyroid hormone receptor and 125I-hTSH as tracer. RESULTS: Nine cases of untreated hyperthyroidism (Hyperthyroidism) were found, and TRAb was all positive. Thyroidism was found in 38 cases of drug-induced hyperthyroidism, of which 30 cases were positive. Both normal control group and simple goiter group were negative. The results suggest that the determination of TRAb by this method may be one of the methods to diagnose and prognose hyperthyroidism.