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一、HIV 感染时的免疫功能失常众所周知,在HIV 感染的相对晚期会出现CD_4~+辅助T 细胞选择性减少。尽管这是HIV 诱导免疫缺陷的主要机制,但已有报道艾滋病人另外还有CD_4~+和CD_8~+T 细胞质的功能性缺陷.不但艾滋病人中有免疫功能异常,而且在无症状者中也存在.在CD_4~+细胞被破坏消除之前,HIV 感染就已影响到T 细胞、B 细胞及单核细胞的功能.体内和体外研究均表明:单核-巨噬细胞和树突状细胞可被HIV 感染并在其中复制。这些抗原辅佐细胞(APC)可能从两方面参与HIV 感染的免疫发病过程.首先,单核-巨噬细胞可能
First, the immune dysfunction of HIV infection is well known that HIV-infected relatively late will appear CD_4 ~ + helper T-cell selective reduction. Although this is the main mechanism of HIV-induced immune deficiency, it has been reported that AIDS patients have other functional defects of CD_4 ~ + and CD_8 ~ + T cytoplasm, not only immune function abnormalities in AIDS patients, but also in asymptomatic HIV infection affects the function of T cells, B cells and monocytes until the destruction of CD 4 + cells, both in vivo and in vitro, show that monocytes - macrophages and dendritic cells can be HIV infection and replication in them. These antigen-assisted cells (APCs) may participate in the immune pathogenesis of HIV infection in two ways.First, mononuclear-macrophages may