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目的：研究白细胞介素－１β、肿瘤环死因子α和白细胞介素－６在瘢痕组织中的表达，并对其意义进行探讨．方法：本文运用免疫组化法，分别应用抗白细胞介素－１β、肿瘤坏死因子α和白细胞介素－６的单克隆抗体，对２０例烧伤患者肉芽和瘢痕组织中白细胞介素－１β、肿瘤坏死因子α和白细胞介素－６的表达水平进行了检测．结果：在伤后一个月的肉芽和三个月的瘢痕组织中白细胞介素－１β、肿瘤坏死因子α和白细胞介素－６有较多表达阳性的细胞，而在伤后一年的晚期瘢痕组织中，上述细胞因子表达阳性的细胞则明显减少．表达阳性的细胞主要为单核巨噬细胞、成纤维细胞和淋巴细胞．结论：免疫细胞通过直接产生或诱导产生的这些细胞因子，对成纤维细胞的增殖调控具有重要的作用，与增生性瘢痕的发生有着密切关系
Objective: To study the expression of interleukin-1β, tumor necrosis factor-α and interleukin-6 in scar tissue and to explore its significance. Methods: Immunohistochemical method was used to detect the expression of interleukin - 1β, tumor in 20 cases of burn patients’ burns with monoclonal antibody against interleukin - 1β, tumor necrosis factor - α and interleukin - 6 Necrosis factor alpha and interleukin-6 expression levels were detected. RESULTS: Interleukin-1β, tumor necrosis factor-α and interleukin-6 were positively expressed in granulation tissue and scar tissue for one month after injury, while in one year after injury, advanced scar Tissue, the above-mentioned cytokine expression of cells was significantly reduced. The positive cells are mainly mononuclear macrophages, fibroblasts and lymphocytes. CONCLUSION: Immune cells play an important role in the regulation of proliferation of fibroblasts through the direct production or induction of these cytokines and are closely related to the occurrence of hypertrophic scars