Louver blinds are commonly used in building designs to avoid excessive solar radiation in an indoor environment, particularly for buildings with highly glazed facades. However, little attention has been given to their impact on flow field and pressure distribution around a building, which is crucial for predicting convective heat transfer, pollutant dispersion, and indoor ventilation. Therefore, the present study combined a wind-tunnel experiment with computational fluid dynamics simulations to study a wind velocity profile, flow field patts, and surface pressure around a cubic building with louver blinds. The louver blinds move windward flow separation in an upward direction and extend the recirculation region of a roof; moreover, some subvortices are generated between the two adjacent louver slats. Louver angle φ, installing distance W, and slat width B severely affect the generation of subvortices between slats and a conical vortex on the roof. Subsequently, blinds with different φ, W, and B exhibit different pressure distributions on the windward surface and top surface of a building.