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[目的]观察双歧杆菌三联活菌胶囊、复方谷氨酰胺肠溶胶囊联合美沙拉嗪对溃疡性结肠炎的疗效,为溃疡性结肠炎临床治疗提供帮助。[方法]入选100例溃疡性结肠炎患者,按随机数字表法分为对照组和治疗组,各50例,对照组患者采用美沙拉嗪治疗,治疗组患者采用双歧杆菌三联活菌胶囊、复方谷氨酰胺肠溶胶囊联合美沙拉嗪治疗,检测2组患者治疗前后总体症状评分、氧化应激指标(GSH-Px、CAT、SOD)、细胞因子(IL-2、TNF-α、IL-6、hs-CRP)及血流动力学指标(WHV、PV、PCV、PAdT)情况。[结果]治疗前2组患者总体症状评分、氧化应激指标、细胞因子及血流动力学指标比较差异无统计学差异(P>0.05)。与治疗前比较,2组患者治疗后IL-2和氧化应激指标均显著升高,总体症状评分、血流动力学指标、MDA以及细胞因子显著降低,差异有统计学意义(P<0.05)。治疗后,治疗组患者IL-2和氧化应激指标显著高于对照组,总体症状评分、血流动力学指标、MDA以及细胞因子显著低于对照组,2组比较差异有统计学意义(P<0.05)。[结论]双歧杆菌三联活菌胶囊、复方谷氨酰胺肠溶胶囊与美沙拉嗪的联合治疗能够改善溃疡性结肠炎患者临床症状及血液情况、降低炎症反应以及防止氧化应激反应的加剧,对溃疡性结肠炎患者的临床治疗具有重要的意义。
[Objective] To observe the curative effect of Bifidobacterium triple viable capsule and compound glutamine enteric-coated capsule combined with mesalazine on ulcerative colitis and provide the help for the clinical treatment of ulcerative colitis. [Methods] One hundred patients with ulcerative colitis were enrolled and randomly divided into control group and treatment group according to random number table method, 50 cases each. Patients in the control group were treated with mesalazine. The patients in the treatment group were treated with live bifidobacterium triple viable capsule, Compound glutamine enteric-coated capsules combined with mesalazine treatment before and after treatment to detect the overall symptom score, oxidative stress indicators (GSH-Px, CAT, SOD), cytokines (IL-2, TNF- 6, hs-CRP) and hemodynamic parameters (WHV, PV, PCV, PAdT). [Results] There was no significant difference in overall symptom score, oxidative stress index, cytokine and hemodynamics between the two groups before treatment (P> 0.05). Compared with those before treatment, the levels of IL-2 and oxidative stress were significantly increased in both groups after treatment, and the overall symptom score, hemodynamic parameters, MDA and cytokines were significantly decreased (P <0.05) . After treatment, the indexes of IL-2 and oxidative stress in the treatment group were significantly higher than those in the control group, and the overall symptom scores, hemodynamics, MDA and cytokines were significantly lower than those in the control group (P <0.05). [Conclusion] The combination therapy of Bifidobacterium triple viable capsule, compound glutamine enteric-coated capsule and mesalazine can improve the clinical symptoms and blood conditions, reduce the inflammatory reaction and prevent the aggravation of oxidative stress in patients with ulcerative colitis, The clinical treatment of patients with ulcerative colitis is of great significance.