目的:制备小儿热清按摩凝胶,并建立其质量控制方法。方法:以柴胡、黄芩等药材的提取物为主药,卡波姆为基质制备凝胶。采用薄层色谱法对方中柴胡、桂枝等药材进行了定性鉴别,采用高效液相色谱法测定黄芩苷含量。结果:所制凝胶为黄色细腻半流体物;薄层色谱斑点显色清晰;黄芩苷检测线性范围为0.1-0.9μg,平均回收率为99.40%。结论:该制剂制备工艺简单,性质稳定,质量控制方法可行。 Objective: To prepare pediatric heat-clearing massage gel and establish its quality control method. Methods: Bupleurum, Radix Scutellariae and other herbs as the main drug, carbomer as a matrix preparation gel. By TLC, the contents of Radix Bupleuri and Guizhi were identified qualitatively and the contents of baicalin were determined by high performance liquid chromatography. Results: The prepared gel was yellow and semi-fluid; the color of TLC was clear; the linear range of baicalin was 0.1-0.9μg, the average recovery was 99.40%. Conclusion: The preparation process is simple, stable in nature and feasible in quality control.