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目的：探讨黄芪注射液对糖尿病患者血清氧自由基、转化生长因子-β1（ transforming growth factor-β，TGF-β1）及血管内皮功能的影响。方法选取2010年12月～2014年12月宁波市第九医院内科收治的2型糖尿病患者124例，采用随机数字表法分为观察组和对照组，观察组联合黄芪注射液，对照组予二甲双胍片，比较2组患者谷胱甘肽过氧化物酶（ glutathione peroxidase，GSH-PX）、过氧化酶超氧化物歧化酶（ superoxide dismutase， SOD ）、丙二醛（ malondialdehyde， MDA ）以及超前氧化蛋白产物（ advanced oxidation protein products，AOPP）的含量，血清 TGF-β1及血管生长因子（ vascular endothelial growth factor， VEGF ）、血管生成素1（angiogenin，ANG-1）水平。结果治疗后，观察组患者血清中MDA、AOPP含量低于对照组，GSH-PX、SOD含量高于对照组；观察组TGF-β1低于对照组；观察组VEGF、ANG-1高于对照组（ P＜0.05）。结论黄芪注射液可以改善糖尿病患者血管内皮功能，降低TGF-β1，改善自由基聚集状态。“,”Objective To investigate the effect of astragalus injection on serum oxygen free radical, TGF-β1 and vascular endothelial function in diabetes mellitus.Methods 120 cases of type 2 diabetic patients were selected from December 2010 to December 2014 as the object of study, 2 groups of patients underwent diabetic education and diet, exercise therapy, the control group were treated with metformin hydrochloride tablets, and the observation group were combined with astragalus injection, the contents of SOD, MDA and GSH-PX were compared between the 2 groups.The serum levels of TGF-β1, VEGF, ANG-1 and AOPP were compared between 2 groups.Results After treatment, comared with control group, the serum MDA and AOPP were higher, the GSH-PX and SOD were higher; the TGF-β1 were lower; the VEGF and ANG-1 were higher in observation group ( P <0.05).Conclusion Astragalus injection could improve the function of vascular endothelium in patients with diabetes, reduce the transforming growth factor β1, improving the free radical aggregation state.