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肌萎缩侧索硬化症(ALS)是一种以选择性运动神经元变性为特征的神经退行性疾病。其病因和发病机制目前仍不明确,且缺乏客观的诊断标准和有效的治疗手段。脑脊液(CSF)能反映中枢神经系统病理生理改变,进行CSF中ALS生物学标志物的筛选将有助于疾病的诊断,为ALS发病机制的探讨提供线索。本文就近年来对ALS患者CSF中生物学标志物的研究作介绍。
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by degeneration of selective motor neurons. The etiology and pathogenesis is still not clear, and the lack of objective diagnostic criteria and effective treatment. Cerebrospinal fluid (CSF) can reflect the pathophysiology of the central nervous system changes, the CSF ALS biomarkers screening will help the diagnosis of the disease, provide a clue for the pathogenesis of ALS. This article in recent years on ALS patients CSF biomarkers for the study.