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目的:探讨肝外胆管癌神经及脉管浸润转移的危险因素。方法:回顾性分析2001年1月—2011年1月收治的128例肝外胆管癌患者的临床病理资料。分析肝外胆管癌神经及脉管浸润转移与临床病理因素之间的关系。结果:128例患者中,神经及脉管浸润转移50例(39.1%)。单因素分析显示,肿瘤大小(P=0.010)和肿瘤浸润深度(P=0.000)与肝外胆管癌神经及脉管浸润转移有关,患者的性别、年龄、乙型肝炎病毒感染、肿瘤部位、肿瘤病理类型、肿瘤分化程度、淋巴结转移和术前血清CA19-9水平均与肝外胆管癌神经及脉管浸润转移无关(P>0.05)。多因素logistic回归分析显示,肿瘤大小和肿瘤浸润深度与神经及脉管浸润转移相关(P<0.05)。结论:肿瘤大小和肿瘤浸润深度是影响肝外胆管癌神经及脉管浸润转移的独立危险因素。
Objective: To explore the risk factors of nerve and vascular invasion and metastasis in extrahepatic cholangiocarcinoma. Methods: The clinical and pathological data of 128 patients with extrahepatic cholangiocarcinoma admitted from January 2001 to January 2011 were retrospectively analyzed. To analyze the relationship between nerve and vascular invasion and metastasis of extrahepatic cholangiocarcinoma and clinicopathological factors. Results: Among the 128 patients, 50 cases (39.1%) had nerve and vascular invasion. Univariate analysis showed that tumor size (P = 0.010) and depth of tumor invasion (P = 0.000) were associated with neural and vascular invasion and metastasis of extrahepatic cholangiocarcinoma. Patient’s gender, age, hepatitis B virus infection, tumor location, tumor The pathological type, tumor differentiation, lymph node metastasis and preoperative serum CA19-9 level had no correlation with the invasion of nerve and vascular invasion of extrahepatic cholangiocarcinoma (P> 0.05). Multivariate logistic regression analysis showed that tumor size and depth of tumor invasion correlated with nerve and vessel invasion and metastasis (P <0.05). Conclusion: The size of tumor and the depth of tumor infiltration are independent risk factors for the invasion of extrahepatic cholangiocarcinoma and vascular invasion.