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环孢菌素可减轻或防止自身免疫性BB鼠的糖尿病发生。人类I型糖尿病确诊后如早期给予足量的环孢菌素可使病情缓解。一种强力的新免疫抑制剂FK506曾广泛用于器官移植中,能象环胞菌素那样抑制T细胞激活,其方式为通过抑制早期淋巴因子(例如白介素-2、白介素-3及γ-干扰素)的mRNA转录。作者为评定FK506对BB鼠糖尿病发病率的作用,将59只7窝BB鼠仔按性别配对随机分为3组,20只每日喂以自来水(对照组),19只每日喂以FK506 1mg/kg(小剂量组),20只每日喂以FK506 2mg/kg(大剂量组)。受治疗鼠年龄为30～120日龄。糖尿病诊断依据为糖尿(一周检测3次)及连续3天非空腹静脉血血糖高于200mg/dl。
Cyclosporine can reduce or prevent the onset of diabetes in autoimmune BB rats. After the diagnosis of human type I diabetes early enough cyclosporine can make the disease remission. A potent new immunosuppressant, FK506, has been widely used in organ transplants to inhibit T cell activation like cyclosporine by inhibiting early lymphokines (such as interleukin-2, interleukin-3, and gamma-interference Prime) mRNA transcription. In order to assess the effect of FK506 on the incidence of diabetes mellitus in BB rats, 59 7-day-old BB rats were randomly divided into 3 groups according to their gender. Twenty (20) rats were fed daily with tap water (control group) and 19 were fed daily with FK506 1 mg / kg (low dose group), 20 daily fed with FK506 2mg / kg (high dose group). Treated mice aged 30 to 120 days of age. The diagnosis of diabetes based on diabetes (3 times a week) and non-fasting blood glucose for 3 days more than 200mg / dl.