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目的:探讨0.5%盐酸丙美卡因滴眼液对弃瓣准分子激光上皮下角膜磨镶术(LASEK)后疼痛的控制以及对术后恢复的影响。方法:选取32例(64眼)行弃瓣LASEK患者,术后24h给予适当点用0.5%盐酸丙美卡因眼药水;另选取40例(80眼)相同术式给予0.5%酮咯酸氨丁三醇滴眼液点眼作为对照。并观察术后疼痛,角膜上皮的愈合,视力恢复及角膜雾浊等发生情况。结果:两组患者在24h内各时间段使用表麻剂组疼痛指数更低,两组间差异有非常显著性(P<0.01)。术后24h使用0.5%盐酸丙美卡因滴眼液的次数为(9.28±2.63)次,间隔时间为(2.91±1.75)h。36h及48h疼痛两组差异无显著性(P>0.05)。两组在角膜上皮愈合,术后视力恢复,角膜雾浊方面差异无显著性(P>0.05)。结论:弃瓣LASEK术后适当使用0.5%盐酸丙美卡因滴眼液能有效解决术后疼痛,并对角膜上皮的愈合无明显影响。
Objective: To investigate the effect of 0.5% proparacaine hydrochloride eye drops on post-LACK pain relief and postoperative recovery. Methods: Thirty-two patients (64 eyes) with LASEK were selected for discard. After 24 hours of operation, 0.5% propionate hydrochloride was given to eye drops. Another 40 eyes (80 eyes) were given the same operation with 0.5% ketorolac Butanetriol eye drops as a control. And observe postoperative pain, corneal epithelial healing, visual acuity and corneal haze and so on. Results: The pain index of ephedrine group and ephedrine group was lower in both groups within 24 hours. There was significant difference between the two groups (P <0.01). The number of 0.5% propanecain hydrochloride eye drops was (9.28 ± 2.63) and the interval time was (2.91 ± 1.75) h after operation. 36h and 48h pain no significant difference between the two groups (P> 0.05). There was no significant difference between the two groups in corneal epithelial healing, postoperative visual acuity recovery and corneal haze (P> 0.05). Conclusion: The appropriate use of 0.5% proparacaine hydrochloride eye drops after the discard of LASEK can effectively relieve postoperative pain and have no significant effect on corneal epithelial healing.