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目的:探讨尿nephrin与肌酐比率(UNCR)和视黄醇结合蛋白4(RBP-4)在2型糖尿病肾病诊断中的意义。方法:选取2型糖尿病患者110例,正常健康对照组40例。采用定量酶联免疫吸附法(ELISA)测定2组患者尿白蛋白、肌酐、nephrin和RBP-4的含量,依据尿白蛋白与肌酐比率(UACR)将糖尿病患者分为正常白蛋白尿组、微量白蛋白尿组和大量白蛋白尿组,进行UNCR与RBP-4相关性分析。结果:正常白蛋白尿组、微量白蛋白尿组和大量白蛋白尿组UNCR比较差异具有统计学意义(P<0.05);正常白蛋白尿组UNCR阳性率为51.7%,而微量白蛋白尿组和大量白蛋白尿组UNCR阳性率均大于95%,UNCR与RBP-4呈正相关。正常白蛋白尿组、微量白蛋白尿组和大量白蛋白尿组RBP-4含量比较差异具有统计学意义(P<0.05)。结论:UNCR和RBP-4在糖尿病早期诊断和预测糖尿病肾病病情进展中有重要的指示作用。
Objective: To investigate the significance of urinary nephrin to creatinine ratio (UNCR) and retinol binding protein 4 (RBP-4) in the diagnosis of type 2 diabetic nephropathy. Methods: 110 type 2 diabetic patients and 40 healthy control subjects were selected. Urinary albumin, creatinine, nephrin and RBP-4 levels in two groups were measured by enzyme-linked immunosorbent assay (ELISA). According to urinary albumin to creatinine ratio (UACR), patients with diabetes were divided into normal albuminuria group, Albuminuria group and a large number of albuminuria group, UNCR and RBP-4 correlation analysis. Results: There were significant differences in UNCR between normal albuminuria group, microalbuminuria group and large albuminuria group (P <0.05). The positive rate of UNCR in normal albuminuria group was 51.7%, while that of microalbuminuria group And a large number of albuminuria UNCR positive rates were greater than 95%, UNCR and RBP-4 was positively correlated. RBP-4 levels in normal albuminuria group, microalbuminuria group and large albuminuria group were significantly different (P <0.05). Conclusion: UNCR and RBP-4 are important indicators in the early diagnosis and prognosis of diabetic nephropathy.