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目的:探讨血清降钙素原(PCT)对于老年心衰患者抗感染治疗中的指导意义。方法:选取我院于2013年1月-2014年6月间收治的130例老年心衰患者,将其随机分为观察组以及对照组,每组65例,对照组根据患者的病情变化决定是否使用抗菌药物,而观察组根据PCT变化决定是否使用抗菌素治疗。比较2组患者的体温、PCT、WBC、CRP变化情况,治疗效果,住院情况以及抗菌素使用情况。结果:观察组在使用抗菌药物当日的PCT水平明显低于入院时,P<0.05,而体温、WBC、CRP水平比较无明显差异,使用抗菌药物3 d后,血清PCT水平相比于使用抗菌素当日明显下降,体温相比于入院时显著下降,P<0.05。观察组的二重感染率明显低于对照组,P<0.05,观察组的抗菌药物使用疗程、费用以及总住院费用均明显低于对照组,组间比较有明显差异,P<0.05。结论:PCT指标应用于老年心衰患者应用抗菌素的指导治疗,能够减少抗菌药物的使用量,降低住院费用,减少住院时间,减少二重感染的发生率。
Objective: To investigate the clinical significance of serum procalcitonin (PCT) in anti-infective therapy in elderly patients with heart failure. Methods: A total of 130 elderly patients with heart failure who were admitted to our hospital from January 2013 to June 2014 were randomly divided into observation group and control group, with 65 cases in each group. The control group decided whether or not to change according to the patient’s condition Antibiotics were used, whereas the observation group decided to use antibiotic treatment based on PCT changes. The changes of body temperature, PCT, WBC and CRP, treatment effect, hospitalization and antibiotic use were compared between the two groups. Results: In the observation group, the PCT level on the day of using antibiotics was significantly lower than that on admission, P <0.05, while there was no significant difference in body temperature, WBC and CRP levels. Compared with the antibiotics Significant decline, body temperature compared to admission significantly decreased, P <0.05. The double infection rate in the observation group was significantly lower than that in the control group (P <0.05). The duration of antimicrobial treatment, cost and total hospitalization cost in the observation group were significantly lower than those in the control group (P <0.05). Conclusion: The application of PCT index in the treatment of elderly patients with heart failure using antibiotics can reduce the usage of antibiotics, reduce hospitalization costs, reduce hospitalization time and reduce the incidence of double infection.