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目的分析婴幼儿呼吸道合胞病毒(RSV)感染与鼻咽分泌物嗜酸性粒细胞的关系,探讨呼吸道病毒感染对过敏及喘息发生的影响。方法选择2002—2004在首都儿科研究所就诊的呼吸道疾病婴幼儿223例,包括肺炎组82例,毛细支气管炎组65例,反复喘息组76例。取患儿鼻咽分泌物,分离培养RSV等7种较常见病毒,并检测嗜酸性粒细胞,进行对比分析。结果3组间病毒检测阳性率不同(P<0·05),RSV检测阳性率差异存在显著性意义(P<0·01);3组患儿鼻咽分泌物嗜酸性粒细胞计数不同(P=0·000),反复喘息组高于毛细支气管组及肺炎组(均P<0·01)。结论RSV是婴幼儿毛细支气管炎、反复喘息和肺炎的主要病原。RSV等病毒感染并不促使过敏的发生。
Objective To analyze the relationship between respiratory syncytial virus (RSV) infection and eosinophilic nasopharyngeal secretion in infants and young children and explore the influence of respiratory virus infection on allergy and wheezing. Methods Totally 223 infants and young children with respiratory diseases were selected from the Capital Institute of Pediatrics from 2002 to 2004, including 82 cases of pneumonia group, 65 cases of bronchiolitis group and 76 cases of recurrent wheezing group. Take nasopharyngeal secretions from children, isolated and cultured seven kinds of viruses such as RSV, and detect eosinophils, for comparative analysis. Results The positive rates of virus detection in the three groups were different (P <0.05), and there was significant difference in the positive rate of RSV (P <0.01). The eosinophil counts of nasopharyngeal secretions in the three groups were different = 0. 000), wheezing group was higher than those in capillary bronchus group and pneumonia group (all P <0.01). Conclusions RSV is the main pathogen of infantile bronchiolitis, wheezing and pneumonia. RSV virus infection does not prompt the occurrence of allergies.