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目的 探讨血清骨钙素测定在佝偻病诊断中的应用。方法 检测 118例佝偻病患儿 (观察组 )及 40例正常儿童 (对照组 )血清骨钙素 (BGP)、血清钙、磷、碱性磷酸酶 ,并同时进行双腕关节X线摄片。结果 观察组及对照组BGP异常升高的检出率分别为 90 .7%和 12 5 % ,两者比较差异有非常显著性 (P <0 .0 1)。观察组检测血清钙、磷、碱性磷酸酶 ,双腕关节X摄片的异常率显著高于对照组 (P <0 0 1)。观察组检测血清钙、磷、碱性磷酸及双腕关节X线摄片异常率分别为 13.6 % ,2 7 1% ,16 9%和 5 0 8% ,均明显低于血清骨钙素的异常检出率 (P <0 .0 1) ,32例佝偻病患儿经维生素D3及钙剂治疗 6周后复查BGP ,2 6例 (81 2 % )降至正常范围。结论 BGP测定是佝偻病早期诊断及观察疗效的一个较敏感的生化指标。
Objective To investigate the application of serum osteocalcin in the diagnosis of rickets. Methods Serum BGP, serum calcium, phosphorus and alkaline phosphatase were detected in 118 cases of rickets (observation group) and 40 normal children (control group). Results The detection rate of abnormal BGP in the observation group and the control group were 90.7% and 125%, respectively. There was significant difference between the two groups (P <0.01). The abnormal rate of serum calcium, phosphorus, alkaline phosphatase and wrist X-ray in the observation group was significantly higher than that in the control group (P <0.01). The abnormal rates of serum calcium, phosphorus, alkaline phosphatase and wrist radiography in the observation group were 13.6%, 27.1%, 16.9% and 58.0%, respectively, which were significantly lower than those of the serum osteocalcin The detection rate (P <0. 01), 32 cases of rickets in children with vitamin D3 and calcium treatment of 6 weeks after the review of BGP, 26 cases (81 2%) fell to the normal range. Conclusion BGP determination is a sensitive biochemical indicator of early diagnosis and observation of rickets.