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目的探讨盐酸米诺环素在种植体周围炎中的应用效果。方法将种植体周围炎患者150例随机分为研究组和对照组,每组75例。2组患者均采用龈下刮治和龈上洁治等常规治疗措施,研究组在常规治疗基础上采用盐酸米诺环素软膏治疗,对照组在常规治疗基础上采用2%碘甘油治疗,观察2组治疗后1、3、6周菌斑指数(PLI)、龈沟出血(SBI)及牙周探诊深度(PD)。结果治疗前2组患者PLI、SBI、PD水平比较差异无统计学意义(P>0.05)。治疗后1、3周2组患者PLI、SBI、PD较治疗前均有改善,且研究组改善程度明显优于对照组,差异均有统计学意义(P<0.05)。治疗后6周2组PLI、SBI及PD水平均升高,但研究组低于对照组(P<0.05)。结论盐酸米诺环素软膏治疗种植体周围炎安全性高,疗效更持久,值得临床推广应用。
Objective To investigate the effect of minocycline hydrochloride in peri-implantitis. Methods 150 patients with peri-implantitis were randomly divided into study group and control group, with 75 cases in each group. The two groups of patients were treated by subgingival scaling and supragingivalgia. The study group was treated with minocycline hydrochloride ointment on the basis of routine treatment, and the control group was treated with 2% iodine glycerol on the basis of conventional treatment The plaque index (PLI), gingival sulcus bleeding (SBI) and periodontal exploration depth (PD) at 1, 3 and 6 weeks after treatment in the two groups. Results There was no significant difference in PLI, SBI and PD between the two groups before treatment (P> 0.05). The PLI, SBI and PD of two groups after 1 and 3 weeks of treatment were improved than those before treatment, and the improvement of the study group was obviously better than that of the control group (P <0.05). The levels of PLI, SBI and PD increased in both groups 6 weeks after treatment, but the study group was lower than the control group (P <0.05). Conclusion Minocycline hydrochloride ointment is safe and effective in the treatment of peri-implantitis. It is worthy of clinical application.