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目的探讨屈螺酮炔雌醇片治疗宫腔镜下子宫内膜息肉电切术后的效果及对子宫内膜息肉复发的预防作用。方法选取2014年1月-2016年3月收治的110例子宫内膜息肉患者,按照随机数字表分为对照组和试验组,每组55例患者。对照组患者在宫腔镜下实施子宫内膜息肉电切术,试验组患者在对照组的治疗基础上术后给予屈螺酮炔雌醇片进行治疗。两组患者均随访半年,比较两组患者的临床疗效、子宫内膜息肉复发情况、不良反应及术后并发症发生情况。结果 110例入选患者均成功完成所有内膜息肉切除,平均手术时间为(22.42±5.13)min,术中出血量为(17.31±2.44)ml。对照组患者的总有效率为81.82%,明显低于试验组(94.55%),差异有统计学意义(χ~2=9.827,P<0.05)。术后6个月时随访,试验组患者子宫内膜息肉复发4例(7.27%),显著低于对照组(13例,23.64%),差异有统计学意义(P<0.05)。两组患者术后均未出现大出血或宫腔粘连、宫腔感染及过度水化综合征等并发症;试验组患者服药后初期有轻微不良反应出现,均自行缓解。结论临床上在宫腔镜下实施子宫内膜息肉电切术后,患者口服屈螺酮炔雌醇片能够较好地恢复正常月经,有效降低了子宫内膜息肉复发率。
Objective To investigate the effect of drospirenone ethinyl estradiol in the treatment of hysteroscopic endometrial polyps resection and its preventive effect on the recurrence of endometrial polyps. Methods A total of 110 patients with endometrial polyps who were admitted from January 2014 to March 2016 were divided into control group and experimental group according to a random number table, with 55 patients in each group. Patients in the control group underwent hysteroscopic resection of endometrial polyp. The patients in the test group were treated with drospirenone ethinyl estradiol tablets after the operation in the control group. The two groups of patients were followed up for six months, the clinical efficacy of two groups were compared, the recurrence of endometrial polyps, adverse reactions and postoperative complications. Results All the 110 patients were successfully performed all the endometrial polypectomy. The average operation time was (22.42 ± 5.13) min, and the intraoperative blood loss was (17.31 ± 2.44) ml. The total effective rate of the control group was 81.82%, which was significantly lower than that of the experimental group (94.55%), the difference was statistically significant (χ ~ 2 = 9.827, P <0.05). At 6 months postoperatively, 4 cases (7.27%) of endometrial polyps recurred in the test group, which was significantly lower than that of the control group (13 cases, 23.64%). The difference was statistically significant (P <0.05). No postoperative bleeding or intrauterine adhesions, intrauterine infection and excessive hydration syndrome and other complications occurred in both groups. Patients in the experimental group had slight adverse reactions at the initial stage after taking the medication, all of which relieved spontaneously. Conclusion After hysteroscopic resection of endometrial polyp resection, oral administration of drospirenone ethinyl estradiol tablets can restore normal menstruation and effectively reduce the recurrence rate of endometrial polyps.