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目的:探讨IgG抗体亚类与新生儿溶血病发病的关系。方法:用ELISA法对89例有无新生儿溶血病新生儿母亲的血清及22例献血员的血清中IgG亚类进行定量分析。结果:发病患儿与不发病新生儿的血型及其母亲血清IgG抗体的效价均存在显著性差异(P<0.05)。IgG各亚类的水平在发病组、未发病组的母体及正常对照组之间,存在显著性差异(P<0.05)。结论:ABO血型系统中,母体血清中IgG1和IgG3的水平与新生儿溶血病的发病有关。
Objective: To investigate the relationship between IgG subclass and hemolytic disease of newborn. Methods: Serum samples from 89 mothers with or without neonatal hemolytic disease and serum IgG from 22 donors were analyzed by ELISA. Results: There was a significant difference in the titers of blood group and mothers’ serum IgG antibody between infants with and without newborns (P <0.05). There was a significant difference in the level of IgG subclass between the onset group and the non-onset group and the normal control group (P <0.05). Conclusion: In the ABO blood group system, the levels of IgG1 and IgG3 in maternal serum are related to the pathogenesis of hemolytic disease in neonates.