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[目的]了解载脂蛋白AV(apoAV)-1131 T>C基因多态性和apoAV水平与非酒精性脂肪性肝病(NAFLD)的关系。[方法]对78例B超确诊为NAFLD患者(NAFLD组)和58例同期体检示非NAFLD者(对照组),采用酶联免疫吸附试验检测血清apoAV浓度进行测定,通过聚合酶联反应-限制性长度多态性方法进行apoAV-1131 T>C基因多态性分析。[结果]NAFLD组的apoAV水平低于对照组、TC基因型频率高于对照组(均P<0.05);TC+CC基因型的血清apoAV水平低于TT基因型、血清三酰甘油水平高于TT基因型(均P<0.05)。[结论]apoAV-1131 T>C位点影响血清apoAV和三酰甘油水平,增加了NAFLD的发病风险。
[Objective] To investigate the relationship between apolipoprotein AV (apoAV) -1131 T> C gene polymorphism and apoAV level with non-alcoholic fatty liver disease (NAFLD). [Methods] 78 patients with NAFLD diagnosed by B-mode ultrasound (NAFLD) and 58 patients with non-NAFLD during the same period were enrolled in this study. Serum apoAV concentration was measured by enzyme-linked immunosorbent assay (ELISA) The polymorphism of apoAV-1131 T> C gene was analyzed by sex-length polymorphism. [Results] The level of apoAV in NAFLD group was lower than that in control group, and the frequency of TC genotype was higher than that in control group (all P <0.05). The level of apoAV in TC + CC genotype was lower than that in TT genotype and the serum triglyceride level was higher TT genotype (all P <0.05). [Conclusion] The apoAV-1131 T> C site affects serum apoAV and triglyceride levels and increases the risk of NAFLD.