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小鼠連續服用甲狀腺素兩週後,對銻銨急性毒性的敏感性顯著增加,而連續服用丙基硫氧嘧啶,則可增加對銻銨急性毒性的耐受性。腹腔注射銻銨於甲狀腺機能亢進狀態,甲狀腺機能不足及正常大鼠後,銻~(124)在组織中分佈的濃度均以肝及胃腸道为最高,腎臟次之,在甲狀腺中的濃度均很低。腹腔注射銻”銨後,銻~(124)的排泄總量三组動物無明顯區别。因此,銻銨對甲狀腺機能亢進狀態,甲狀腺機能不足及正常小鼠毒性的不同,似並非由於注射銻銨後,銻的分佈和排泄不同所致。
After two consecutive weeks of taking thyroxine in mice, the sensitivity to acute toxicity of antimony was significantly increased, while continuous administration of propylthiouracil increased the tolerance to the acute toxicity of antimony. Intraperitoneal injection of antimony ammonium in hyperthyroidism, hypothyroidism and normal rats, antimony ~ (124) in the distribution of tissue concentrations were highest in the liver and gastrointestinal tract, followed by the kidneys in thyroid concentrations were Very low. Antimony ~ (124) excretion of the total amount of three groups of animals no significant difference.Therefore, antimony ammonium hypothyroidism, thyroid hypothyroidism and normal toxicity of different mice, it seems not due to the injection of antimony After the ammonium, antimony distribution and excretion due to different.