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松果腺褪黑素可使正常动物和人的血压降低,也可对抗病理性的血压升高.其作用机制:(1)通过视交叉上核、下丘脑-垂体-肾上腺轴以及下丘脑前核等作用于心血管系统,产生降压作用,此为褪黑素降压的中枢机制;(2)作用于外周血管内皮细胞及其他组织等,发挥扩血管、抗氧化、抗炎等效应,从而使血压下降,此为褪黑素降压的外周机制.总之,褪黑素主要是通过中枢和外周双重机制来发挥降压作用的.
Melatonin melatonin can reduce blood pressure in normal animals and humans, but also against pathological blood pressure.Its mechanism of action: (1) through the suprachiasmatic nucleus, hypothalamus - pituitary - adrenal axis and the hypothalamus before Nuclear role in the cardiovascular system, resulting in antihypertensive effect, which is melatonin central mechanism of antihypertensive; (2) role in peripheral vascular endothelial cells and other organizations, to play the vasodilator, anti-oxidation, anti-inflammatory effect, Thus lowering the blood pressure, which is the peripheral mechanism of melatonin antihypertension.In short, melatonin exerts its antihypertensive effect mainly through the central and peripheral dual mechanisms.